In Vitro Evaluation of Adsorption Properties of Various Devices for Selective Lipopolysaccharide Hemoperfusion (Experimental Study)

The objective: to study in vitro adsorption properties of various devices for selective lipopolysaccharide (LPS) adsorption. Subjects and Methods: Various methods closed circuit circulating bovine serum endotoxin solutions were used. was perfused using an LPS sorption device 240 min. Serum samples collected before the start perfusion, 30, 60, 120, 150, minutes after circulation. concentrations measured by turbidimetric method. One column polymyxin hemoperfusion three lipopolysaccharides assessed. Results: When hemoperfusion, concentration decreased 61% during 120 minutes, additional administration endotoxin, it went down 57%. other devices, these parameters made 9% 6%, 10% 8%, 5% 10%, respectively. C onclusion. By definition, cannot provide complex pathophysiological reactions occurring body sepsis. Тhis fact leads limitations extrapolating results obtained clinical practice.